Real-time observation of pathophysiological processes during murine experimental Schistosoma japonicum infection using high-resolution ultrasound imaging

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Real-time observation of pathophysiological processes during murine experimental Schistosoma japonicum infection using high-resolution ultrasound imaging

Background Hepatosplenic lesion formation is one of the typical clinical symptoms of schistosomiasis japonica. Although it is established that circum-oval granuloma formation mediated by T lymphocytes is the key event triggering the formation of hepatic lesions, the time-course kinetics of disease progression remains to be fully elucidated. Methods The real-time process of the pathophysiology...

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Molecular Differentiation of Schistosoma japonicum and Schistosoma mekongi by Real-Time PCR with High Resolution Melting Analysis

Human schistosomiasis caused by Schistosoma japonicum and Schistosoma mekongi is a chronic and debilitating helminthic disease still prevalent in several countries of Asia. Due to morphological similarities of cercariae and eggs of these 2 species, microscopic differentiation is difficult. High resolution melting (HRM) real-time PCR is developed as an alternative tool for the detection and diff...

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High-range-resolution imaging using frequency domain interferometry with stabilization techniques for real-time vascular ultrasound

1Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan 2Department of Anatomy, Shiga University of Medical Science, Otsu 520-2192, Japan 3Advanced Biomedical Engineering Research Unit, Kyoto University, Kyoto 606-8501, Japan 4Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan 5Graduate School of Informatics, Kyoto University, Kyoto 606-8501, Japan E-mail: t...

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MicroRNA-Gene Expression Network in Murine Liver during Schistosoma japonicum Infection

BACKGROUND Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries. The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge. However, the molecular mechanism underling the hepatic pathogenesis is still not clear. METHODO...

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High prevalence of Schistosoma japonicum infection in water buffaloes in the Philippines assessed by real-time polymerase chain reaction.

Difficulty in controlling human Schistosoma japonicum infection is partly attributed to the presence of non-human definitive hosts. Water buffaloes are a major reservoir for transmission of S. japonicum to humans in China. However, in the Philippines, reports based on microscopic examination of buffalo stool identified a low prevalence of S. japonicum, and mathematical models using these data c...

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ژورنال

عنوان ژورنال: Tropical Medicine and Health

سال: 2018

ISSN: 1349-4147

DOI: 10.1186/s41182-017-0082-5